Adenylate Cyclase Inhibitor

Adenylate Cyclase Inhibitors (33):

Cat. No.	Product Name	Effect	Purity

HY-100396

SQ22536	Inhibitor	99.98%
SQ22536 is an effective adenylate cyclase (AC) inhibitor.

HY-135878

2',5'-Dideoxyadenosine	Inhibitor	99.93%
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC₅₀ of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart.

HY-103194

KH7	Inhibitor	≥99.0%
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sAC_t protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.

HY-169263

AC10142A	Inhibitor
AC10142A is a selective Adenylyl Cyclase Type 1 inhibitor with IC₅₀ of 0.26 μM. AC10142A can be used to study pain models.

HY-100524

LRE1	Inhibitor	99.76%
LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

HY-132298

TDI-10229	Inhibitor	99.84%
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC₅₀ of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.

HY-101279

ST034307	Inhibitor	98.46%
ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC₅₀ of 2.3 μM.

HY-B1124

Fipexide	Inhibitor
Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.

HY-103192

MDL12330A	Inhibitor	99.82%
MDL12330A (RMI12330A) is an adenyl cyclase inhibitor. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC). MDL12330A is also an inhibitor of cAMP phosphodiesterase.

HY-151798

TDI-11861	Inhibitor	98.39%
TDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor with slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC₅₀ value of 5.5 nM.

HY-P99509

Zelminemab	Inhibitor	98.79%
Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor.

HY-B1124A

Fipexide hydrochloride	Inhibitor	99.88%
Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research. Fipexide hydrochloride acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.

HY-103195

NKY80	Inhibitor	99.69%
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.

HY-P2090A

Angiopeptin TFA	Inhibitor	99.71%
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

HY-116530

9-Cyclopentyladenine monomethanesulfonate	Inhibitor	99.16%
9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties.

HY-101862

CB-7921220	Inhibitor	≥98.0%
CB-7921220 is an adenylate cyclase inhibitor.

HY-145830

AC1-IN-1	Inhibitor	99.81%
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.

HY-N10772

Albanin A	Inhibitor
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-14425

NB001	Inhibitor	98.7%
NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity.

HY-115748A

Mant-GTPγS triammonium	Inhibitor
Mant-GTPγS triammonium, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS triammonium is a potent YdeH inhibitor.

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